On long time scales, the random Brownian motion of particles diffusing in a liquid is well described by theories developed by Einstein and others, but the instantaneous or short time scale behavior has been much harder to observe or analyze. Kheifets et al. (p. 1493) combined ultrasensitive position detection with sufficient data collection to probe the Brownian motion of microbeads in fluids on time scales that are shorter than the characteristic bead-fluid interaction time.