Jamie GOULD

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Name:
Organization: University of Leeds , England
Department: School of Chemistry
Title: Lecture(PhD)
Co-reporter:Laurence J. Kershaw Cook, Rachel Kearsey, Jessica V. Lamb, Edward J. Pace, Jamie A. Gould
Tetrahedron Letters 2016 Volume 57(Issue 8) pp:895-898
Publication Date(Web):24 February 2016
DOI:10.1016/j.tetlet.2016.01.043
A novel methodology to synthesise oligo-(1H-pyrazol-4-yl)-arenes with controllable size, shape and steric bulk from 1-trityl-1H-pyrazol-4-ylboronate pinacol esters. This straightforward and efficient procedure can be applied to a variety of brominated aromatic precursors in a manner which leaves the pyrazole NH intact for further modification or coordination to metal ions. This will enable the synthesis of novel bioactive molecules and molecular material precursors, all achievable without any purification techniques beyond standard extraction and trituration.
1H-Pyrazole, 4,4'-[1,1'-biphenyl]-4,4'-diylbis[3,5-dimethyl-
4-(3,5-dimethyl-1h-pyrazol-4-yl)benzoic Acid
1H-Pyrazole, 4,4'-(1,4-phenylene)bis[3,5-dimethyl-
1H-Pyrazole, 4-bromo-3,5-dimethyl-1-(triphenylmethyl)-
4-(1H-Pyrazol-4-yl)benzoic acid
1H-Pyrazole, 4,4'-(1,4-phenylene)bis-