BENZYL-PYRIDIN-4-YLMETHYL-AMINE

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CAS: 73325-67-4
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Synonyms: BENZYL-PYRIDIN-4-YLMETHYL-AMINE

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F. Christopher Pigge

University of Iowa
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Co-reporter: Lokesh Pawar, F. Christopher Pigge
pp: 6067-6070
Publication Date(Web):6 November 2013
DOI: 10.1016/j.tetlet.2013.08.110
4-Alkylpyridines functionalized with alkynyl amide substituents can be converted to pyridyl-substituted lactams via Au-catalyzed cyclization at the pyridine benzylic carbon. These transformations proceed through alkylidene dihydropyridine (anhydrobase) intermediates and demonstrate the ability to utilize these species in metal-catalyzed C–C bond forming reactions.Image for unlabelled figureFigure optionsDownload full-size imageDownload as PowerPoint slide